Friday, May 4, 5:00 PM

Wayne M. Yokoyama
Washington Univ. Sch. of Med., AAI President
50 years (well, almost!) in immunology

Emil R. Unanue, Washington Univ. Sch. of Med.
Introduction

Into the Limelight: Natural Killer and Innate Lymphoid Cells

Monday, May 7, 12:30 – 2:30 PM

Chair:
Wayne M. Yokoyama, Washington Univ. Sch. of Med. in St. Louis, AAI President

Speakers:

• David H. Raulet, Univ. of California, Berkeley, NK cell activation and inactivation in the tumor microenvironment
• Katharine C. Hsu, Mem. Sloan Kettering Cancer Ctr., NK cells in the oncology clinic
• Gabrielle T. Belz, Walter and Eliza Hall Inst. of Med. Res., Australia, Teasing apart transcriptional regulation in innate lymphoid cells
• Marco Colonna, Washington Univ. Sch. of Med., Innate lymphoid cell plasticity

David H. Raulet

Katharine C. Hsu

Gabrielle T. Belz

Marco Colonna

Saturday, May 5, 6:00 PM

Jeffrey A. Bluestone
Univ. of California, San Francisco
Treg-mediated immune tolerance in health and disease

Sunday, May 6, 6:00 PM

Pamela J. Fink
Univ. of Washington Sch. of Med.
Educating T cells from the cradle through adolescence

Monday, May 7, 6:00 PM

Randolph J. Noelle
Dartmouth Geisel Sch. of Med.
A panoramic VISTA of the immune system

Saturday, May 5, 8:00 AM – 11:30 AM

Major Symposium A: Transcriptional Control of Immunity: Diverse Regulatory Mechanisms in Gene Regulation
Chairs:
Amy S. Weinmann, Univ. of Alabama, Birmingham
Boris Reizis, New York Univ. Sch. of Med.

Speakers:

• Amy S. Weinmann, Univ. of Alabama, Birmingham, Role for metabolites in regulating cellular differentiation gene programs
• Boris Reizis, New York Univ. Sch. of Med., Transcriptional control of dendritic cell function in vivo
• Tracy L. Johnson, Univ. of California, Los Angeles, TBA
• Jorge Henao-Mejia, Univ. of Pennsylvania, Regulation of innate immune cells by lncRNAs
• Andrea Schietinger, Mem. Sloan Kettering Cancer Ctr., Molecular mechanisms defining tumor-specific T cell differentiation and dysfunction
• Stephen T. Smale, Univ. of California, Los Angeles, Mechanisms regulating selective transcriptional responses to innate immune stimuli

Major Symposium B: Immune Cells in Tissue Niches
Chairs:
Frederic Geissmann, Mem. Sloan Kettering Cancer Ctr.
Gretchen Diehl, Baylor Col. of Med.

Speakers:

• Shannon J. Turley, Genentech, Stromal niche in cancer immunology and immunotherapy
• Frederic Geissmann, Mem. Sloan Kettering Cancer Ctr., Roles of resident macrophages in brain, bone, and fat tissue homeostasis
• Robyn S. Klein, Washington Univ. Sch. of Med., CNS immunity: new players in neuroprotection
• Jun R. Huh, Harvard Med. Sch., Maternal gut bacteria, immune cells, and neurodevelopmental disorder
• Gretchen Diehl, Baylor Col. of Med., Microbial regulation of intestinal immunity
• Bruno Lemaitre, Global Hlth. Inst., EPFL Lausanne, Switzerland, Regulation of Drosophila hemocyte number and sessility by an adipokine

Sunday, May 6, 8:00 AM – 11:30 AM

Major Symposium C: New Regulatory Concepts from Human Immunology Studies
Chairs:
Bana Jabri, Univ. of Chicago
Michael J. Lenardo, NIAID, NIH

Speakers:

• Bana Jabri, Univ. of Chicago, TBA
• Michael J. Lenardo, NIAID, NIH, New precision medicine therapies emerge from genomic investigation of diseases of the immune system
• Luis Barreiro, Univ. of Montreal/CHU Sainte-Justine, Canada, Genetic and environmental determinants of interindividual variation in immune responses to infection
• Federica Sallusto, Inst. for Res. in Biomed., USI and ETH Zurich, Switzerland, Lymphocyte diversity: matching specificity and function
• Ramnik J. Xavier, Harvard Univ. and Broad Inst., Human genetics to innate immune pathways
• Maria Grazia Roncarolo, Stanford Sch. of Med., New Regulatory Concepts from Human Immunology Studies

Major Symposium D: Gone but not Forgotten: the Impact of Cell Death on the Immune Response
Chairs:
Carla V. Rothlin, Yale Sch. of Med.
Andrew A. Oberst, Univ. of Washington

Speakers:

• Shigekazu Nagata, iFREC, Osaka Univ., Exposure of phospatidylserine on apoptotic cells
• Julie Magarian Blander, Weill Cornell Med., Phagocyte responses to dying cells
• Carla V. Rothlin, Yale Sch. of Med., Death begets a new beginning: recognition of apoptotic cells in the induction of tissue repair
• Ross M. Kedl, Univ. of Colorado Denver Sch. of Med., Lymphatic endothelial cell death as a vehicle for antigen exchange and maintenance of T cell memory
• Andrew A. Oberst, Univ. of Washington, The innate immune response to Zika virus infection of the central nervous system
• Thirumala-Devi Kanneganti, St. Jude Children’s Res. Hosp., Regulation of inflammasome activation and cell death

Monday, May 7, 8:00 AM – 11:30 AM

Major Symposium E: Developing more Effective Cancer Immunotherapies
Chairs:
Robert D. Schreiber, Washington Univ. Sch. of Med.
Nina Bhardwaj, Icahn Sch. of Med. at Mt. Sinai

Speakers:

• James P. Allison, Univ. of Texas MD Anderson Cancer Ctr., Immune Checkpoint Blockade in Cancer Therapy: New Insights and Opportunities, and prospects for Cures
• Robert D. Schreiber, Washington Univ. Sch. of Med., Elucidating the fundamental principles of personalized cancer vaccines
• Nina Bhardwaj, Icahn Sch. of Med. at Mt. Sinai, Targeting dendritic cells to modulate antitumor immunity
• Sandra Demaria, Weill Cornell Med., Insights into the mechanisms regulating antigenicity and adjuvanticity of irradiated tumors
• Patrick A. Ott, Dana Farber Cancer Inst., Brigham and Women’s Hosp., and Harvard Med. Sch., A personal neoantigen vaccine in patients with high risk melanoma
• Philip D. Greenberg, Univ. of Washington and Fred Hutchinson Cancer Res. Ctr., Engineering T cell responses to effectively target and then eliminate tumors

Major Symposium F: Immune – Microbe Coevolution
Chairs:
James R. Carlyle, Univ. of Toronto, Canada
Janelle S. Ayres, Salk Inst.

Speakers:

• James R. Carlyle, Univ. of Toronto, Canada, Immune evasion, adaptation, and escape: the MCMV m12 immunoevasin controls NK cell immunity by targeting the prototypical NKR-P1 family
• Janelle S. Ayres, Salk Inst., Host-Microbe Interactions: Harnessing Co-evolution to Treat Disease
• Nichole R. Klatt, Univ. of Washington, Microbial interactions in HIV infection
• David Wang, Washington Univ. Sch. of Med., Lessons from novel viruses in infection and immunity
• Lisa Osborne, Univ. of British Columbia, Canada, Host-multibiome interactions in intestinal infection and inflammation
• Russell E. Vance, HHMI and Univ. of California, Berkeley, How do inflammasomes detect rapidly evolving pathogens?

Tuesday, May 8, 8:00 AM – 11:30 AM

Major Symposium G: Molecular Basis of B cell Differentiation and Function
Chairs:
Jennifer L. Gommerman, Univ. of Toronto, Canada
Ignacio Sanz, Emory Univ. Sch. of Med.

Speakers:

• Troy D. Randall, Univ. of Alabama, Birmingham, Resident memory B cells in the lung
• Ignacio Sanz, Emory Univ. Sch. of Med., B cell differentiation pathways in human SLE
• Christopher Scharer, Emory Univ. Sch. of Med., Cell division coupled epigenetic regulation of B cell differentiation
• Marion Pepper, Univ. of Washington, Understanding somatically hypermutated IgM memory B cells
• Facundo Batista, Ragon Inst. of MGH, MIT and Harvard, B cell activation induces a switch from canonical to non-canonical autophagy that shapes B cell fate
• Jennifer Anolik, Univ. of Rochester Med. Ctr., B cell roles in bone homeostasis in rheumatoid arthritis

Major Symposium H: Neuroscience of Immunity
Chairs:
Kevin J. Tracey, Feinstein Inst. for Med. Res.
Tajie H. Harris, Univ. of Virginia

Speakers:

• Kevin J. Tracey, Feinstein Inst. for Med. Res., Molecular basis for reflex integration of
  immunity
• Tajie H. Harris, Univ. of Virginia, Glia-derived signals promote focal protective immunity to CNS infection
• Isaac M. Chiu, Harvard Med. Sch., Nociceptor neuron regulation of innate immunity and host defense
• Paul Kubes, Univ. of Calgary, Canada, Using imaging to study the neural – immune interplay
• Betty Diamond, Feinstein Inst. for Med. Res., Antibodies, microglial activation and cognitive impairments
• Diana Bautista, Univ. of California, Berkeley, TBA

AAI Clinical Immunology Committee
Reverse Translation – Learning from the Patient
Chairs:
Thomas F. Gajewski, Univ. of Chicago Med. Ctr.; AAI Clinical Immunology Committee Chair
Megan Sykes, Columbia Univ.

AAI Committee on Public Affairs
NIH Efforts to Fund the Next Generation: Progress, Challenges and Future Directions
Chair:
Beth A. Garvy, Univ. of Kentucky; AAI Committee on Public Affairs Chair

AAI Education Committee
Careers in Biotech: Panel Discussion and Networking
Chair:
Kerry A. Casey, MedImmune

Immunology Teaching Interest Group
Chairs:
Anil K. Bamezai, Villanova Univ.
David W. Mullins, Dartmouth Col.

AAI Education Committee & AAI Committee on the Status of Women
Careers in Science Roundtable
Chair:
Laura A. Solt, Scripps Res. Inst.; AAI Committee on the Status of Women Chair

AAI Minority Affairs Committee
Careers Roundtable and Speed Networking Session
Chair:
Robert J. Binder, Univ. of Pittsburgh; AAI Minority Affairs Committee Chair

AAI Vanguard Lecture

Speaker:

• Elina Zuniga, Univ. of California, San Diego, The art of coexistence: immune adaptations during chronic viral infections

Since 2003, the AAI meeting has featured a scientific lecture presented by an AAI member who is an underrepresented minority investigator noted for scientific achievement and exemplary career success.

AAI Program Committee
Back to School: A Review of Four Fast-Moving Fields
Chairs:
Eugene M. Oltz, Washington Univ. Sch. of Med., AAI Program Committee Chair
Jennifer A. Punt, Univ. of Pennsylvania Sch. of Vet. Med.

AAI Publications Committee
Writing Scientific Manuscripts and Responding to Reviewers: Tips on Navigating the Process
Chairs:
Brian Evavold, Univ. of Utah; Chair, AAI Publications Committee Chair
Pamela J. Fink, Univ. of Washington Sch. of Med.; Editor-in-Chief, The Journal of Immunology

AAI Veterinary Immunology Committee
Neonatal Immunity: Getting it Right from the Start
Chairs:
Crystal Loving, Natl. Animal Dis. Ctr., ARS, USDA; AAI Veterinary Immunology Committee Chair
George Mutwiri, Univ. of Saskatchewan